A five-year study of genetic data has uncovered a new genetic variation linked to Alzheimer's disease. Studying the Alzheimer's-related faulty processing of amyloid precursor protein (APP), researchers found that this was linked with two variations in the SORL1 gene.
"We discovered two different variants in the SORL1 gene that are associated with increased risk of AD in different ethnic groups, says Dr. Ekaterina Rogaeva, first author of the study and also part of CRND. "This emphasizes the complexity of the genetics of common late-onset form of Alzheimer's disease, and has important implications for replication studies that would need to assess SORL1 variations in datasets with similar genetic background."
Read more: Alzheimer's gene identified: study
ABSTRACT: The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease